Essential role of ATG7 in LPS-induced endometrial inflammatory injury in goats

Abstract The economic losses caused by uterine infections in ruminants have received increasing attention. Autophagy-related 7 ( ATG7 ) has been demonstrated to be capable of regulating apoptosis, but surprisingly, can both promote and inhibit apoptosis different cellular contexts. However, the role endometrial cell during postpartum period remains unclear. Herein, location expression was determined after mice were treated with lipopolysaccharide (LPS) uterus. results showed that increased epithelial cells (EECs) not stromal cells. goat EECs under LPS treatment, further led an increase bax a decline bcl-2 EECs. Silencing inhibited EEC treatment. regulation confirmed overexpression. may serve as essential regulatory factor process inflammatory injury. findings help elucidate pathogenesis endometritis ruminants.